مقایسه اثر عصاره آبی چای سبز و کاتچین بر سطح سرمی گنادوتروپین، استرادیول، پروژسترون، تستوسترون و فولیکول‌های تخمدان در موش صحرایی مدل سندرم تخمدان پلی‌کیستیک

Background and Aim: Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder, which is characterized by ovulatory dysfunction and hyperandrogenism. Regarding to the antioxidant properties of green tea (Camellia sinensis) compounds, the present study was done to evaluate the effect of aqueous extract of green tea and catechin on the status of sex hormones and ovaries in polycystic ovarian syndrome rat model. Materials and Methods: In this experimental study, 42 Wistar female rats were divided into 7 equal groups of control, PCOS control, PCOS treated with aqueous extract of green tea (50 and 100 mg/kg, 24 days, ip), PCOS treated with catechin (50 and 100 mg/kg, 24 days, ip) and PCOS treated with clomiphene citrate (1.5 mg/kg, 24 days, ip). Polycystic ovarian syndrome was induced by a single intramuscular injection of estradiol valerate (4 mg/kg). At the end of administration period, serum level of LH, FSH, &beta;-estradiol, Progesterone, and testosterone was measured using ELISA. Also, the number of ovarian follicles was counted. The obtained data was analyzed using one-way ANOVA and Post Hoc Tukey statistical tests. Results: Compared to PCOS control group, serum level of LH, &beta;-estradiol, testosterone and number of cystic follicles in the groups treated with clomiphene citrate, treated with 100 mg/kg aqueous extract of green tea and treated with 50 and 100 mg/kg of catechin significantly decreased, but serum level of FSH, progesterone and number of preantral, antral, preovulatory follicles, and corpus luteum significantly increased (p<0.05). Conclusion: Compared with green tea, catechin has a more favorable effect on improving hormonal parameters, especially FSH hormone and increasing the number of ovarian follicles in rats with polycystic ovary syndrome.